Journal of Medicinal Chemistry
Volume 40, Issue 25 (December 5, 1997)
Copyright © 1997 American Chemical Society

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3991-3991

Accelerated Electronic Publication Philip S. Portoghese Editor-in-Chief [Full Article - PDF]

3992-3996

A Modular Lymphographic Magnetic Resonance Imaging Contrast Agent: Contrast Enhancement with DNA Transfection Potential Erik R. Wisner, Kimberly L. Aho-Sharon, Michael J. Bennett, Sharron G. Penn, Carlito B. Lebrilla, and Michael H. Nantz [Full Article - PDF]

3997-4005

Examination of the Role of the Acidic Hydrogen in Imparting Selectivity of 7-(Aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) Toward Inhibition of Phenylethanolamine N-Methyltransferase vs the 2-Adrenoceptor1a Gary L. Grunewald, Vilas H. Dahanukar,1b Timothy M. Caldwell, and Kevin R. Criscione [Full Article - PDF]

4006-4012

Screening Solution-Phase Combinatorial Libraries Using Pulsed Ultrafiltration/Electrospray Mass Spectrometry Yong-Zhong Zhao, Richard B. van Breemen, Dejan Nikolic, Chao-Ran Huang, Charles P. Woodbury, Alexander Schilling, and Duane L. Venton [Full Article - PDF]

4013-4018

Intensely Cytotoxic Anthracycline Prodrugs: Glucuronides Elena Bakina, Zheng Wu, Michael Rosenblum, and David Farquhar [Full Article - PDF]

4019-4025

1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine Hydrochloride (BTCP) Yields Two Active Primary Metabolites in Vitro: Synthesis, Identification from Rat Liver Microsome Extracts, and Affinity for the Neuronal Dopamine Transporter Carine Deleuze-Masquefa, Martine Michaud, Jacques Vignon, and Jean-Marc Kamenka [Full Article - PDF]

4026-4029

(Aryloxy)alkylamines as Selective Human Dopamine D4 Receptor Antagonists: Potential Antipsychotic Agents Paul C. Unangst, Thomas Capiris, David T. Connor, Robert Doubleday, Thomas G. Heffner, Robert G. MacKenzie, Steven R. Miller, Thomas A. Pugsley, and Lawrence D. Wise [Full Article - PDF]

4030-4052

Design and Synthesis of Benzoic Acid Derivatives as Influenza Neuraminidase Inhibitors Using Structure-Based Drug Design Pooran Chand, Yarlagadda S. Babu, Shanta Bantia, Naiming Chu, L. Brent Cole, Pravin L. Kotian, W. Graeme Laver, John A. Montgomery, Ved P. Pathak, Sandra L. Petty, David P. Shrout, David A. Walsh, and Gerald M. Walsh [Full Article - PDF]

4053-4068

Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists Michael Rowley, Janusz J. Kulagowski, Alan P. Watt, Denise Rathbone, Graeme I. Stevenson, Robert W. Carling, Raymond Baker, George R. Marshall, John A. Kemp, Alan C. Foster, Sarah Grimwood, Richard Hargreaves, Catherine Hurley, Kay L. Saywell, Mark D. Tricklebank, and Paul D. Leeson [Full Article - PDF]

4069-4078

Cationic Lipid-Mediated Gene Delivery to Murine Lung: Correlation of Lipid Hydration with in Vivo Transfection Activity Michael J. Bennett, Alfred M. Aberle, Rajiv P. Balasubramaniam, Jill G. Malone, Robert W. Malone, and Michael H. Nantz [Full Article - PDF]

4079-4088

Nonsymmetrically Substituted Cyclic Urea HIV Protease Inhibitors Wendell W. Wilkerson, Scott Dax, and Walter W. Cheatham [Full Article - PDF]

4089-4102

A Strategy for the Incorporation of Water Molecules Present in a Ligand Binding Site into a Three-Dimensional Quantitative Structure-Activity Relationship Analysis Manuel Pastor, Gabriele Cruciani, and Kimberly A. Watson [Full Article - PDF]

4103-4112

Identification of Novel Farnesyl Protein Transferase Inhibitors Using Three-Dimensional Database Searching Methods James J. Kaminski, D. F. Rane, Mark E. Snow, Lois Weber, Marnie L. Rothofsky, Samantha D. Anderson, and Stanley L. Lin [Full Article - PDF]

4113-4135

Peptidomimetic Inhibitors of the Human Cytomegalovirus Protease William Ogilvie, Murray Bailey, Marc-André Poupart, Abraham Abraham, Amit Bhavsar, Pierre Bonneau, Josée Bordeleau, Yves Bousquet, Catherine Chabot, Jean-Simon Duceppe, Gulrez Fazal, Sylvie Goulet, Chantal Grand-Maître, Ingrid Guse, Ted Halmos, Pierre Lavallée, Michael Leach, Eric Malenfant, Jeff O'Meara, Raymond Plante, Céline Plouffe, Martin Poirier, François Soucy, Christiane Yoakim, and Robert Déziel [Full Article - PDF]

4136-4145

Assessment of Solvation Effects on Calculated Binding Affinity Differences: Trypsin Inhibition by Flavonoids as a Model System for Congeneric Series. Ana Checa, Angel R. Ortiz, Beatriz de Pascual-Teresa, and Federico Gago [Full Article - PDF]

4146-4153

Synthesis and Pharmacological Evaluation of Triflate-Substituted Analogues of Clozapine: Identification of a Novel Atypical Neuroleptic Yi Liao, Peter DeBoer, Eddie Meier, and Håkan Wikström [Full Article - PDF]

4154-4159

On the Conformation of Tiazofurin Analogues Gergely M. Makara and György M. Keserû [Full Article - PDF]

4160-4160

Current Directions in Radiopharmaceutical Research and Development. Edited by Stephen J. Mather. Kluwer Academic Publishers, Boston, MA. 1996. xvi + 237 pp. 16.5 × 24.5 cm. ISBN 0-7923-4254-2. $136.00. Crist N. Filer [Full Article - PDF]

4160-4160

Circular Dichroism and Linear Dichroism Alison Rodger and Bengt Nordén. Oxford University Press, Oxford, U.K. 1997. x + 150 pp. 19.5 × 25 cm. ISBN 0-19-855897-X. $60.00. Lee Webb [Full Article - PDF]

4160-4161

Glycopeptides and Related Compounds. Synthesis, Analysis, and Applications Edited by D. G. Large and C. D. Warren. Marcel Dekker, Inc., New York. 1997. xii + 767 pp. 18.5 × 26 cm. ISBN-0-8247-9531-8. $195.00. Robert H. Mazur [Full Article - PDF]

4161-4161

Handbook of Phase I/II Clinical Drug Trials Edited by John O'Grady and Peter H. Joubert. CRC Press, Boca Raton, FL. 1997. xii + 562 pp. 18.5 × 26 cm. ISBN 0-8493-9230-6. $149.95. [Full Article - PDF]

4161-4161

Methods in Molecular Biology. Volume 78. Antibacterial Peptide Protocols Edited by William S. Shafer. The Humana Press, Totowa, NJ. 1997. x + 259 pp. 15.5 × 23.5 cm. ISBN 0-89603-408-9. $74.50. Staff [Full Article - PDF]

4161-4162

List of MAK and BAT Values 1996 Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area Report No. 32. Deutsche Forschungsgemeinschaft. Authorized by H. Green. VCH Verlagsgesellschaft mbH, Weinheim, Germany. 1996. xxii + 180 pp. 17 × 24 cm. ISBN 3-527-27572-X. DM 64.00 (pbk). Staff [Full Article - PDF]

4162-4162

Landmarks in Gene Regulation Edited by D. S. Latchman. Portland Press Ltd., London. 1997. xii + 302 pp. 21 × 30 cm. ISBN 1-85578-109-3. $34.00 (pbk). Staff [Full Article - PDF]

4162-4162

Controlled Drug Delivery. Challenges and Strategies Edited by Kinam Park. American Chemical Society, Washington, D.C. 1997. xvii + 629 pp. 20 × 24 cm. ISBN 0-8412-3418-3. $149.95. Staff [Full Article - PDF]

4162-4163

High Throughput Screening. The Discovery of Bioactive Substances, 1997 Edited by John P. Devlin. Marcel Dekker, Inc., New York. 1997. xxiv + 673 pp. 18.5 × 26 cm. ISBN 0-8247-0067-8. $165.00. Donald T. Witiak [Full Article - PDF]

4163-4163

Cytochromes P450. Structure, Function, and Mechanism By David F. Lewis. Taylor & Francis, London and Bristol, PA. 1996. xxi + 348 pp. 17.5 × 25 cm. ISBN 0-7484-0443-0. $150.00. James R. Halpert [Full Article - PDF]

4163-4163

Ligand-Receptor Energetics. A Guide for the Perplexed By Irving M. Klotz. John Wiley & Sons, Inc., New York. 1997. xi + 170 pp. 15.5 × 23 cm. ISBN 0-471-17626-5. $44.95. Staff [Full Article - PDF]

4163-4164

Molecular Mechanics Across Chemistry By Anthony K. Rappé and Carla J. Casewit. University Science Books, Susalito, CA. 1997. xii + 444 pp. 18.5 × 26 cm. ISBN 0-935702-77-6. $56.50. V. Mohan [Full Article - PDF]

4164-4164

Cancer Therapeutics: Experimental and Clinical Agents Edited by Beverly A. Teicher. Humana Press, Totowa, NJ. 1996. x + 451 pp. 18 × 26 cm. ISBN 0-89603-460-7. $125.00. Mark E. Salvati [Full Article - PDF]

4164-4165

Antidepressants. New Pharmacological Strategies Edited by P. Skolnick. Humana Press, Totowa, NJ. 1997. x + 257 pp. 18.5 × 26 cm. ISBN-0-89603-469-0. $99.50. Roger M. Pinder [Full Article - PDF]

4165-4165

NMR Spectroscopy and Its Application to Biomedical Research Edited by Susanta K. Sarkar. Elsevier Science, Amsterdam, The Netherlands. 1996. xviii + 387 pp. 15.5 × 23 cm. ISBN 0-444-89410-1. $250.00. Rickey P. Hicks [Full Article - PDF]

4165-4166

Comprehensive Heterocyclic Chemistry II Edited by A. R. Katritzky, C. W. Rees, and E. F. V. Scriven. Pergamon Press, Elsevier Science, Ltd., Tarrytown, NY. 1996. 12 Volumes: Vol. 1A, xxvii + 505 pp; Vol. 1B, 860 pp; Vol. 2, xiii + 1102 pp; Vol. 3, xiii + 932 pp; Vol. 4, xxiii + 1006 pp; Vol. 5, xxiii + 794 pp; Vol. 6, xxiii + 1307 pp; Vol. 7, xxiii + 1044 pp; Vol. 8, xv + 1326 pp; Vol. 9, xvii + 1146 pp; Vol. 10, xix + 729 pp; Vol. 11, xi + 596 pp. 19.5 × 28 cm. ISBN 0-08-042724-3; 0-08-042725-1; 0-08-042726-X; 0-08-042727-8; 0-08-042728-6; 0-08-042729-4; 0-08-042730-8; 0-08-042731-6; 0-08-042732-4; 0-08-042965-3; 0-08-042987-4. $6345.00 (set). Joseph G. Cannon [Full Article - PDF]

4166-4166

Books of Interest [Full Article - PDF]

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4168-4168

Reliability of CoMFA Models: Effects of Data Scaling and Variable Selection using a Set of Human Synovial Fluid Phospholipase A2 InhibitorsPrediction of Drug Binding Affinities by Comparative Binding Energy Analysis Angel R. Ortiz, Manuel Pastor, Albert Palomer, Gabriele Cruciani, Federico Gago, and Rebecca C. Wade , Angel R. Ortiz, M. Teresa Pisabarro, Federico Gago, and Rebecca C. Wade [Full Article - PDF]